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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 January 2021

Dendrites and disease

Dendrites and disease

(p.677) Chapter 24 Dendrites and disease

Daniel Johnston

Andreas Frick

Nicholas P. Poolos

Oxford University Press

While the functional properties of dendrites in the normal brain are the main focus for this book, there is a long history of research related to changes in dendrites that are associated with certain neurological, psychiatric, and developmental disorders. This chapter focuses on the current state of knowledge related to dendritic “channelopathies.” These are defined as genetic or acquired defects in the normal function or expression of ion channels (with a focus on voltage-gated ion channels) that are known to regulate how neuronal dendrites process and store information. The most specific and detailed information is available for epilepsy, which is discussed at some length, but data are presented for certain neurodevelopmental disorders (autism, fragile X syndrome) and diseases of the adult and aging brain. Based on our knowledge of the normal properties of dendrites, a framework is provided for understanding how dendritic channelopathies can influence synaptic integration and plasticity.

Keywords:   channelopathies, voltage-gated ion channels, epilepsy, autism, fragile X syndrome, psychiatric disorders, synaptic integration, synaptic plasticity

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