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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 January 2021

Local translation in dendrites

Local translation in dendrites

(p.129) Chapter 5 Local translation in dendrites

Irena Vlatkovic

Erin M. Schuman

Oxford University Press

Neurons are unique among cells with their highly polarized and elaborate dendritic and axonal arbors. Synapses, the sites of communication, are located from microns up to a meter from the cell body and rely on proteins for communication and plasticity. In order to acquire proteins to replace those that turn over and to modify synapses, neurons use mRNAs and local protein synthesis. Local translation from dendritically localized mRNAs provides the possibility for rapid and localized response of the neuron to outside stimuli. This chapter reviews and discusses the evidence for local translation in dendrites, its regulation, roles in synaptic plasticity, learning, and memory as well as how it is dysregulated in neurodegenerative and neurodevelopmental disorders. A number of technologies that are used, or could be used, to deepen our understanding of the contribution of local translation to neuronal function are presented.

Keywords:   local translation, mRNA, synapses, synaptic plasticity, neuronal function, technologies, neurodegenerative disorders

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