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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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Subcellular distribution of ligand- and voltage-gated ion channels

Subcellular distribution of ligand- and voltage-gated ion channels

(p.191) Chapter 7 Subcellular distribution of ligand- and voltage-gated ion channels

Zoltan Nusser

Oxford University Press

This chapter describes the subcellular distribution of ligand- and voltage-activated ion channels on the neuronal surface, as detected with a variety of light- and electron-microscopic immunolocalization techniques. First, a general overview is provided demonstrating a presynaptic input- and postsynaptic cell type-dependent location of AMPA- and NMDA-type glutamate and GABAA receptors in the postsynaptic densities of glutamatergic and GABAergic synapses, respectively. Next, the cell type-dependent distribution of voltage-gated channels is described: the HCN1 subunit has a uniform distribution on the somato-dendritic surface of external tufted cells of the olfactory bulb, its density increases as a function of distance from the soma in the dendrites of cortical and hippocampal pyramidal cells (PCs), and it is present exclusively in the axons of many types of GABAergic interneurons. Detailed analysis of the densities of six different Na+ and K+ channel subunits on the axo-somato-dendritic surface of hippocampal PCs revealed that each subunit has its own distribution pattern, rendering the ion channel composition of each subcellular compartment—such as the presynaptic active zone, axon terminals, axon initial segment, soma, proximal, distal dendrites, dendritic spines—unique.

Keywords:   immunolocalization, light-microscopy, electron-microscopy, distribution, hippocampus, olfactory bulb, ion channel, axon, dendrites

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