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Evolution in Health and Disease - Oxford Scholarship Online
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Evolution in Health and Disease

Stephen C. Stearns and Jacob C. Koella


It is now increasingly acknowledged that an evolutionary perspective can give us important new insights into issues central to medical research and practice. This fully revised and updated edition, which consists of roughly 95% new material, contains contributions from leading researchers who provide a fresh summary of this rapidly expanding field. It takes a broad approach to the subject, discussing medically relevant research from evolutionary genetics, evolutionary ecology, evolutionary epidemiology, the evolution of aging, and any other biological disciplines where evolutionary approaches ... More

Keywords: human history, human genetic variation, evolutionary conflicts, reproduction, spontaneous abortion, antibiotic resistance, virulence, vaccination risks, cancer, autoimmune disease

Bibliographic Information

Print publication date: 2007 Print ISBN-13: 9780199207466
Published to Oxford Scholarship Online: April 2010 DOI:10.1093/acprof:oso/9780199207466.001.0001


Affiliations are at time of print publication.

Stephen C. Stearns, editor
Yale University

Jacob C. Koella, editor
Imperial College London

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Part I Introduction

Chapter 1 Introducing Evolutionary Thinking For Medicine

Stephen C. Stearns, Randolph M. Nesse, and David Haig

Part II The history and variation of human genes

Chapter 2 Global spatial patterns of infectious diseases and human evolution

Jean-François Guégan, Franck Prugnolle, and Frédéric Thomas

Chapter 3 Medically relevant variation in the human genome

Diddahally R. Govindaraju, and Lynn B Jorde

Chapter 4 Health consequences of ecogenetic variation

Michael Bamshad, and Arno G. Motulsky

Chapter 5 Human genetic variation of medical significance

Kenneth K. Kidd, and Judith R. Kidd

Part III Natural selection and evolutionary conflicts

Chapter 7 How hormones mediate trade-offs in human health and disease

Richard G. Bribiescas, and Peter T. Ellison

Part IV Pathogens: resistance, virulence, variation, and emergence

Chapter 11 Pathogen evolution in a vaccinated world

Andrew F. Read, and Margaret J. Mackinnon

Chapter 13 Evolutionary origins of diversity in human viruses

Paul M. Sharp, Elizabeth Bailes, and Louise V Wain

Chapter 16 Emergence of new infectious diseases

Mark Woolhouse, and Rustom Antia

Chapter 17 Evolution of parasites

Jacob C. Koella, and Paul Turner

Part V Noninfectious and degenerative disease

Chapter 19 Evolution, developmental plasticity, and metabolic disease

Christopher W. Kuzawa, Peter D. Gluckman, Mark A. Hanson, and Alan S. Beedle

Chapter 22 Cancer as a microevolutionary process

Natalia L. Komarova, and Dominik Wodarz

End Matter