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Micro/Nano Technology Systems for Biomedical ApplicationsMicrofluidics, Optics, and Surface Chemistry$
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Chih-Ming Ho

Print publication date: 2010

Print ISBN-13: 9780199219698

Published to Oxford Scholarship Online: September 2010

DOI: 10.1093/acprof:oso/9780199219698.001.0001

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(p.346) 10 Nanobiosensors
Micro/Nano Technology Systems for Biomedical Applications

Tza‐Huei Wang

Kelvin Liu

Hsin‐Chih Yeh

Christopher M. Puleo

Oxford University Press

This chapter discusses and provides insight into state of the art nanobiosensors used in high sensitivity molecular analysis and detection. It begins with an introduction into the fundamental considerations of nanobiosensor design. To date, a myriad of sensors has been developed based on a wide array of nanomaterials using both optical and electrical signal transduction methods. Illustrative examples of various nanobiosensors based on metallic nanoparticles, semiconductor nanocrystals, and nanowire/nanotubes are given and organized according to the specific signal transduction mechanisms employed. Finally, single molecule detection methods are discussed as techniques to accurately analyze and quantify the output signal of fluorescent nanobiosensors. The chapter concludes with a brief prospective into the future of nanomaterials based sensing systems.

Keywords:   nanobiosensors, metallic nanoparticles, semiconductor nanocrystals, quantum dots, nanowires, nanotubes, confocal fluorescence spectroscopy, single molecule detection

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