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Micro/Nano Technology Systems for Biomedical ApplicationsMicrofluidics, Optics, and Surface Chemistry$
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Chih-Ming Ho

Print publication date: 2010

Print ISBN-13: 9780199219698

Published to Oxford Scholarship Online: September 2010

DOI: 10.1093/acprof:oso/9780199219698.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 29 November 2021

Surface Molecular Property Control

Surface Molecular Property Control

(p.395) 11 Surface Molecular Property Control
Micro/Nano Technology Systems for Biomedical Applications

Robin L. Garrell

Heather D. Maynard

Oxford University Press

Current technologies to modify surfaces and control the surface properties are reviewed, with particular emphasis on alterations for biomedical and bioanalytical applications. A brief tutorial on the mechanisms of biomolecular adsorption provides background for understanding the relationship between surface wettability and biomolecular (particularly protein) adsorption. Methods for modifying surface wettability, materials that minimize or prevent fouling, and techniques for assessing protein fouling and the effectiveness of surface modifications are reviewed. Examples of “designer surfaces” are given, ranging from dynamic coatings in which small molecules or polymers are adsorbed on device surfaces, to covalent modifications such as PEGylation, hydrogel assembly, and the use of functionalized alkyl silanes. New device materials, including hydrogels made from PEGylated monomers, biodegradable polyesters, and photocurable perfluoropolyethers, are also discussed. The chapter closes with approaches that lead to the direct and indirect capture of proteins and peptides and the integration of live cells with microfluidic devices.

Keywords:   wettability, protein adsorption, covalent modifications, polymer, hydrogel, cells, dynamic coatings, PEGylation, alkyl silanes, devices

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