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A Decade of HAARTThe Development and Global Impact of Highly Active Antiretroviral Therapy$
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José M. Zuniga, Alan Whiteside, Amin Ghaziani, and John G. Bartlett

Print publication date: 2008

Print ISBN-13: 9780199225859

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780199225859.001.0001

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The clinical challenges of lifetime HAART

The clinical challenges of lifetime HAART

(p.421) Chapter 26 The clinical challenges of lifetime HAART
A Decade of HAART

Roger Paredes

Renslow Sherer

Bonaventura Clotet

Oxford University Press

This chapter summarizes the principal challenges of antiretroviral therapy (ART) in both resource-rich and developing world settings as of the end of year 2006 and discusses the options available to address them. It shows that long-term ART involves problems of adherence, resistance and toxicity as well as cost. It also shows how the successes of HAART have modified the clinical presentation of cancers in HIV-infected individuals and how the aging of HIV-positive patients is gradually increasing the development of geriatric syndromes that were rarely seen just a few years ago. Early detection and aggressive management of hepatitis co-infections are needed in order to avoid the severe complications and elevated mortality of end-stage liver disease.

Keywords:   highly active antiretroviral therapy, HIV/AIDS, treatment, long-term ART

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