- Title Pages
- Foreword and introduction
- Introduction to the Meeting in Kristineberg, Sweden
- Contributors
- CHAPTER 1 The early days of paleogenetics: connecting molecules to the planet
- CHAPTER 2 Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling
- CHAPTER 3 Linking sequence to function in drug design with ancestral sequence reconstruction
- CHAPTER 4 Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences
- CHAPTER 5 Probabilistic ancestral sequences based on the Markovian model of evolution: algorithms and applications
- CHAPTER 6 Estimating the history of mutations on a phylogeny
- CHAPTER 7 Coarse projections of the protein-mutational fitness landscape
- CHAPTER 8 Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution
- CHAPTER 9 Evolutionary properties of sequences and ancestral state reconstruction
- CHAPTER 10 Reconstructing the ancestral eukaryote: lessons from the past
- CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
- CHAPTER 12 Reconstruction of ancestral proteomes
- CHAPTER 13 Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters
- CHAPTER 14 Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays
- CHAPTER 15 Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins
- CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function
- CHAPTER 17 A thermophilic last universal ancestor inferred from its estimated amino acid composition
- CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine
- CHAPTER 19 Evolution of specificity and diversity
- Conclusion and a way forward
- Index
Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
- Chapter:
- (p.117) CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
- Source:
- Ancestral Sequence Reconstruction
- Author(s):
Xun Gu
Ying Zheng
Yong Huang
Dongping Xu
- Publisher:
- Oxford University Press
This chapter presents a new approach to functional divergence analysis with the combination of ancestral sequence inference, using the family of animal G-protein subunits as an example. Using the method, the evolutionary trends of two types of functional divergence of amino acid residues after gene duplication are traced. These pieces of evolutionary information are useful for making testable hypotheses about functional divergence between protein subfamilies, such as subtypes of G-protein subunits, which can be verified by further experimentation.
Keywords: functional divergence analysis, G-protein subunits, amino acid, evolution
Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.
Please, subscribe or login to access full text content.
If you think you should have access to this title, please contact your librarian.
To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .
- Title Pages
- Foreword and introduction
- Introduction to the Meeting in Kristineberg, Sweden
- Contributors
- CHAPTER 1 The early days of paleogenetics: connecting molecules to the planet
- CHAPTER 2 Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling
- CHAPTER 3 Linking sequence to function in drug design with ancestral sequence reconstruction
- CHAPTER 4 Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences
- CHAPTER 5 Probabilistic ancestral sequences based on the Markovian model of evolution: algorithms and applications
- CHAPTER 6 Estimating the history of mutations on a phylogeny
- CHAPTER 7 Coarse projections of the protein-mutational fitness landscape
- CHAPTER 8 Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution
- CHAPTER 9 Evolutionary properties of sequences and ancestral state reconstruction
- CHAPTER 10 Reconstructing the ancestral eukaryote: lessons from the past
- CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
- CHAPTER 12 Reconstruction of ancestral proteomes
- CHAPTER 13 Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters
- CHAPTER 14 Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays
- CHAPTER 15 Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins
- CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function
- CHAPTER 17 A thermophilic last universal ancestor inferred from its estimated amino acid composition
- CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine
- CHAPTER 19 Evolution of specificity and diversity
- Conclusion and a way forward
- Index
