- Title Pages
- Foreword and introduction
- Introduction to the Meeting in Kristineberg, Sweden
- Contributors
- CHAPTER 1 The early days of paleogenetics: connecting molecules to the planet
- CHAPTER 2 Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling
- CHAPTER 3 Linking sequence to function in drug design with ancestral sequence reconstruction
- CHAPTER 4 Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences
- CHAPTER 5 Probabilistic ancestral sequences based on the Markovian model of evolution: algorithms and applications
- CHAPTER 6 Estimating the history of mutations on a phylogeny
- CHAPTER 7 Coarse projections of the protein-mutational fitness landscape
- CHAPTER 8 Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution
- CHAPTER 9 Evolutionary properties of sequences and ancestral state reconstruction
- CHAPTER 10 Reconstructing the ancestral eukaryote: lessons from the past
- CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
- CHAPTER 12 Reconstruction of ancestral proteomes
- CHAPTER 13 Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters
- CHAPTER 14 Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays
- CHAPTER 15 Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins
- CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function
- CHAPTER 17 A thermophilic last universal ancestor inferred from its estimated amino acid composition
- CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine
- CHAPTER 19 Evolution of specificity and diversity
- Conclusion and a way forward
- Index
Using ancestral gene resurrection to unravel the evolution of protein function
Using ancestral gene resurrection to unravel the evolution of protein function
- Chapter:
- (p.183) CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function
- Source:
- Ancestral Sequence Reconstruction
- Author(s):
Joseph W. Thornton
Jamie T. Bridgham
- Publisher:
- Oxford University Press
This chapter reviews the use of ancestral gene resurrection to understand how the members of a biologically crucial gene family, the steroid hormone receptors, evolved their diverse and highly specific functions. It also discusses some methodological questions and concerns — particularly related to uncertainty in the reconstruction of ancestral sequences — and point to potential future directions for the budding field of ancestral gene resurrection. Topics covered include the evolution of molecular interactions, steroid hormones and their receptors, evolution of corticoid receptor specificity, and evolution of the MR-aldosterone interaction.
Keywords: steroid hormone receptors, evolution, ancestral sequences, molecular interactions, corticoid receptors
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- Title Pages
- Foreword and introduction
- Introduction to the Meeting in Kristineberg, Sweden
- Contributors
- CHAPTER 1 The early days of paleogenetics: connecting molecules to the planet
- CHAPTER 2 Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling
- CHAPTER 3 Linking sequence to function in drug design with ancestral sequence reconstruction
- CHAPTER 4 Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences
- CHAPTER 5 Probabilistic ancestral sequences based on the Markovian model of evolution: algorithms and applications
- CHAPTER 6 Estimating the history of mutations on a phylogeny
- CHAPTER 7 Coarse projections of the protein-mutational fitness landscape
- CHAPTER 8 Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution
- CHAPTER 9 Evolutionary properties of sequences and ancestral state reconstruction
- CHAPTER 10 Reconstructing the ancestral eukaryote: lessons from the past
- CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
- CHAPTER 12 Reconstruction of ancestral proteomes
- CHAPTER 13 Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters
- CHAPTER 14 Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays
- CHAPTER 15 Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins
- CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function
- CHAPTER 17 A thermophilic last universal ancestor inferred from its estimated amino acid composition
- CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine
- CHAPTER 19 Evolution of specificity and diversity
- Conclusion and a way forward
- Index
