- Title Pages
- Foreword and introduction
- Introduction to the Meeting in Kristineberg, Sweden
- Contributors
- CHAPTER 1 The early days of paleogenetics: connecting molecules to the planet
- CHAPTER 2 Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling
- CHAPTER 3 Linking sequence to function in drug design with ancestral sequence reconstruction
- CHAPTER 4 Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences
- CHAPTER 5 Probabilistic ancestral sequences based on the Markovian model of evolution: algorithms and applications
- CHAPTER 6 Estimating the history of mutations on a phylogeny
- CHAPTER 7 Coarse projections of the protein-mutational fitness landscape
- CHAPTER 8 Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution
- CHAPTER 9 Evolutionary properties of sequences and ancestral state reconstruction
- CHAPTER 10 Reconstructing the ancestral eukaryote: lessons from the past
- CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
- CHAPTER 12 Reconstruction of ancestral proteomes
- CHAPTER 13 Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters
- CHAPTER 14 Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays
- CHAPTER 15 Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins
- CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function
- CHAPTER 17 A thermophilic last universal ancestor inferred from its estimated amino acid composition
- CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine
- CHAPTER 19 Evolution of specificity and diversity
- Conclusion and a way forward
- Index
The resurrection of ribonucleases from mammals: from ecology to medicine
The resurrection of ribonucleases from mammals: from ecology to medicine
- Chapter:
- (p.208) CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine
- Source:
- Ancestral Sequence Reconstruction
- Author(s):
Slim O. Sassi
Steven A. Benner
- Publisher:
- Oxford University Press
Ribonucleases, well-known digestive enzymes that supported the development of much of protein science, emerged through an evolutionary history having a rich history of functional recruitment. This chapter reviews paleogenetic studies that explored changing function in this family. Similar approaches promise to be powerful tools to advance medicine in a post-genomic world.
Keywords: Ribonucleases, digestive enzymes, post-genomic, protein science
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- Title Pages
- Foreword and introduction
- Introduction to the Meeting in Kristineberg, Sweden
- Contributors
- CHAPTER 1 The early days of paleogenetics: connecting molecules to the planet
- CHAPTER 2 Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling
- CHAPTER 3 Linking sequence to function in drug design with ancestral sequence reconstruction
- CHAPTER 4 Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences
- CHAPTER 5 Probabilistic ancestral sequences based on the Markovian model of evolution: algorithms and applications
- CHAPTER 6 Estimating the history of mutations on a phylogeny
- CHAPTER 7 Coarse projections of the protein-mutational fitness landscape
- CHAPTER 8 Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution
- CHAPTER 9 Evolutionary properties of sequences and ancestral state reconstruction
- CHAPTER 10 Reconstructing the ancestral eukaryote: lessons from the past
- CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
- CHAPTER 12 Reconstruction of ancestral proteomes
- CHAPTER 13 Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters
- CHAPTER 14 Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays
- CHAPTER 15 Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins
- CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function
- CHAPTER 17 A thermophilic last universal ancestor inferred from its estimated amino acid composition
- CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine
- CHAPTER 19 Evolution of specificity and diversity
- Conclusion and a way forward
- Index
