- Title Pages
- Foreword and introduction
- Introduction to the Meeting in Kristineberg, Sweden
- Contributors
-
CHAPTER 1 The early days of paleogenetics: connecting molecules to the planet -
CHAPTER 2 Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling -
CHAPTER 3 Linking sequence to function in drug design with ancestral sequence reconstruction -
CHAPTER 4 Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences -
CHAPTER 5 Probabilistic ancestral sequences based on the Markovian model of evolution: algorithms and applications -
CHAPTER 6 Estimating the history of mutations on a phylogeny -
CHAPTER 7 Coarse projections of the protein-mutational fitness landscape -
CHAPTER 8 Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution -
CHAPTER 9 Evolutionary properties of sequences and ancestral state reconstruction -
CHAPTER 10 Reconstructing the ancestral eukaryote: lessons from the past -
CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication -
CHAPTER 12 Reconstruction of ancestral proteomes -
CHAPTER 13 Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters -
CHAPTER 14 Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays -
CHAPTER 15 Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins -
CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function -
CHAPTER 17 A thermophilic last universal ancestor inferred from its estimated amino acid composition -
CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine -
CHAPTER 19 Evolution of specificity and diversity - Conclusion and a way forward
- Index
The resurrection of ribonucleases from mammals: from ecology to medicine
The resurrection of ribonucleases from mammals: from ecology to medicine
- Chapter:
- (p.208) CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine
- Source:
- Ancestral Sequence Reconstruction
- Author(s):
Slim O. Sassi
Steven A. Benner
- Publisher:
- Oxford University Press
Ribonucleases, well-known digestive enzymes that supported the development of much of protein science, emerged through an evolutionary history having a rich history of functional recruitment. This chapter reviews paleogenetic studies that explored changing function in this family. Similar approaches promise to be powerful tools to advance medicine in a post-genomic world.
Keywords: Ribonucleases, digestive enzymes, post-genomic, protein science
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- Title Pages
- Foreword and introduction
- Introduction to the Meeting in Kristineberg, Sweden
- Contributors
-
CHAPTER 1 The early days of paleogenetics: connecting molecules to the planet -
CHAPTER 2 Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling -
CHAPTER 3 Linking sequence to function in drug design with ancestral sequence reconstruction -
CHAPTER 4 Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences -
CHAPTER 5 Probabilistic ancestral sequences based on the Markovian model of evolution: algorithms and applications -
CHAPTER 6 Estimating the history of mutations on a phylogeny -
CHAPTER 7 Coarse projections of the protein-mutational fitness landscape -
CHAPTER 8 Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution -
CHAPTER 9 Evolutionary properties of sequences and ancestral state reconstruction -
CHAPTER 10 Reconstructing the ancestral eukaryote: lessons from the past -
CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication -
CHAPTER 12 Reconstruction of ancestral proteomes -
CHAPTER 13 Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters -
CHAPTER 14 Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays -
CHAPTER 15 Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins -
CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function -
CHAPTER 17 A thermophilic last universal ancestor inferred from its estimated amino acid composition -
CHAPTER 18 The resurrection of ribonucleases from mammals: from ecology to medicine -
CHAPTER 19 Evolution of specificity and diversity - Conclusion and a way forward
- Index
