Jump to ContentJump to Main Navigation
Statistics and Informatics in Molecular Cancer Research$
Users without a subscription are not able to see the full content.

Carsten Wiuf and Claus L. Andersen

Print publication date: 2009

Print ISBN-13: 9780199532872

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780199532872.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 September 2021

Methods for derivation of LOH and allelic copy numbers using SNP arrays

Methods for derivation of LOH and allelic copy numbers using SNP arrays

Chapter:
(p.52) 3 Methods for derivation of LOH and allelic copy numbers using SNP arrays
Source:
Statistics and Informatics in Molecular Cancer Research
Author(s):

Carsten Wiuf

Philippe Lamy

Claus L. Andersen

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199532872.003.0003

This chapter discusses statistical methods to derive loss-of-heterozygosity (LOH) and allele specific copy numbers in cancer cells. SNP arrays enable simultaneous information about thousands of DNA markers and their allele specific copy numbers, but to extract the information advanced statistical tools are required. The chapter shows how Hidden Markov Models (HMM) can be applied to infer LOH from genotype data and how the allele intensities are informative about allelic copy number. The methods are illustrated by examples.

Keywords:   genotype, loss-of-heterozygosity, allelic copy number, DNA marker, Hidden Markov Model

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .