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Crystals, X-rays and Proteins – Comprehensive Protein Crystallography - Oxford Scholarship Online
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Crystals, X-rays and Proteins: Comprehensive Protein Crystallography

Dennis Sherwood and Jon Cooper


This book presents a complete account of the theory of the diffraction of X-rays by crystals with particular reference to the processes of determining the structures of protein molecules. The book develops from first principles all relevant mathematics, diffraction, and wave theory. The practical aspects of sample preparation and X-ray data collection using both laboratory and synchrotron sources are covered along with data analysis at both the theoretical and practical levels. The important role played by the Patterson function in structure analysis by both molecular replacement and experimen ... More

Keywords: X-ray crystallography, proteins, diffraction, symmetry, Fourier transform, electron density, solving the phase problem, refinement

Bibliographic Information

Print publication date: 2010 Print ISBN-13: 9780199559046
Published to Oxford Scholarship Online: January 2011 DOI:10.1093/acprof:oso/9780199559046.001.0001


Affiliations are at time of print publication.

Dennis Sherwood, author
Managing Director, The Silver Bullet Machine Manufacturing Company

Jon Cooper, author
Department of Medicine, University College, London