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Placebo EffectsUnderstanding the mechanisms in health and disease$
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Fabrizio Benedetti

Print publication date: 2008

Print ISBN-13: 9780199559121

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780199559121.001.0001

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Clinical–ethical implications and applications

Clinical–ethical implications and applications

(p.239) Chapter 10 Clinical–ethical implications and applications
Placebo Effects

Fabrizio Benedetti

Oxford University Press

The recent neurobiological advances in placebo research can stimulate the development of new clinical trial designs for the validation of new treatments, and lead to an uncertainty principle, whereby it is not possible to understand fully the action of a therapeutic agent. One of the main implications of the recent advances of placebo research is the possibility to induce drug-like effects without drugs, thus opening up the possibility to reduce drug intake. As social stimuli may activate the same biochemical and receptorial pathways onto which drugs act, several cognitive and affective factors can eventually modulate the action of drugs.

Keywords:   clinical trials, therapy, drug intake, ethics, clinical practice

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