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Sleep, Health and SocietyFrom Aetiology to Public Health$
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Francesco P. Cappuccio, Michelle A. Miller, and Steven W. Lockley

Print publication date: 2010

Print ISBN-13: 9780199566594

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780199566594.001.0001

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Sleep, inflammation, and disease

Sleep, inflammation, and disease

(p.239) Chapter 11 Sleep, inflammation, and disease
Sleep, Health and Society

M.A. Miller

F.P. Cappuccio

Oxford University Press

Sleep is a fundamental requirement for living individuals. Emerging evidence suggests that disturbances in sleep and sleep disorders play a role in the morbidity of chronic conditions including obesity and hypertension. This chapter discusses the possibility that the relationship between sleep and CVD may be mediated by inflammatory mechanisms. It examines possible effects of age, gender, ethnicity, etc., on the relationship between sleep and disease progression, along with the role of inflammation in the relationship between known sleep disorders and cardiovascular risk. In particular, the role of inflammatory activation in individuals with obstructive sleep apnoea (OSA) is examined. Whilst evidence may suggest that sleep-curtailment may lead to an increase in the inflammatory processes underlying these diseases, further research is required to determine if biologically restorative sleep can reverse or halt such disease progression.

Keywords:   inflammation, obstructive sleep apnoea, innate immunity, toll-like receptors, OSA, sleep

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