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Sleep, Health and SocietyFrom Aetiology to Public Health$
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Francesco P. Cappuccio, Michelle A. Miller, and Steven W. Lockley

Print publication date: 2010

Print ISBN-13: 9780199566594

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780199566594.001.0001

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Genetics and sleep

Genetics and sleep

(p.269) Chapter 12 Genetics and sleep
Sleep, Health and Society

M.A. Miller

Oxford University Press

Sleep is a complex phenotype and as such it is possible that there are numerous genes which may each have a number of effects that control an individual's sleep pattern. An individual's sleep duration and quality may also be influenced by the interaction of their genes with the environment. This chapter considers some of the genes that are known to be involved in normal sleep regulation. In addition, it examines evidence which suggests that there may be a genetic component to the pathology of some of the known sleep disorders including obstructive sleep apnoea, narcolepsy, Kleine–Levin syndrome, and different parasomnias including sleepwalking and restless leg syndrome. As our understanding of the genetic regulation of sleep in health and disease improves it is anticipated that new diagnostic and treatment options including genetic counselling, improved therapeutic regimes and new drug treatments may arise.

Keywords:   polymorphism, gene, mutation, environmental interactions, heritable, obstructive sleep apnoea, narcolepsy, Kleine–Levin syndrome, parasomnia, sleepwalking

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