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TobaccoScience, policy and public health$
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Peter Boyle, Nigel Gray, Jack Henningfield, John Seffrin, and Witold Zatonski

Print publication date: 2010

Print ISBN-13: 9780199566655

Published to Oxford Scholarship Online: September 2010

DOI: 10.1093/acprof:oso/9780199566655.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 16 January 2021

The changing cigarette: chemical studies and bioassays

The changing cigarette: chemical studies and bioassays

(p.93) Chapter 6 The changing cigarette: chemical studies and bioassays

Ilse Hoffmann

Dietrich Hoffmann

Oxford University Press

This chapter discusses the identification of carcinogens and tumour promoters in tobacco smoke, changes in cigarette smoke composition with various design changes, and observations on cigarette smokers. Major modifications in the make-up of the commercial cigarette were introduced between 1950 and 1975, but since that time there have been few substantive changes toward a further reduction of the toxic and carcinogenic potential of cigarette smoke. A variety of changes in cigarette design and filtration have resulted in chemical changes in cigarette smoke, some of which have demonstrated decreased toxicity in animal assays. Changes in the agricultural, curing, and manufacturing processes of cigarettes have increased the amounts of tobacco-specific nitrosamines in cigarette smoke. These changes are considered to have contributed to the increase in adenocarcinoma of the lung observed over the past several decades.

Keywords:   cigarettes, smoking, carcinogens, tobacco smoke, cigarette smoke, cigarette smokers

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