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Mechanisms of Life History EvolutionThe Genetics and Physiology of Life History Traits and Trade-Offs$
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Thomas Flatt and Andreas Heyland

Print publication date: 2011

Print ISBN-13: 9780199568765

Published to Oxford Scholarship Online: December 2013

DOI: 10.1093/acprof:oso/9780199568765.001.0001

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The genetics of dietary modulation of lifespan

The genetics of dietary modulation of lifespan

Chapter 14 The genetics of dietary modulation of lifespan
Mechanisms of Life History Evolution

Johannes H. Bauer

Stephen L. Helfand

Oxford University Press

Reducing the calories in the diet of animals has long been known to extend life span significantly in the majority of species tested. Even in cases where life span is not extended, the animals experience beneficial effects on overall health. Understanding the molecular basis for these effects will make it possible to develop interventions that might reproduce its beneficial health effects in humans. This chapter summarizes what is currently known about calorie restriction/dietary restriction in a variety of model systems and highlights the molecular events that mediate its effects.

Keywords:   calorie restriction, aging, lifespan, longevity, dietary restriction, nutrition, insulin signaling, TOR signaling, sirtuins

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