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Mechanisms of Life History EvolutionThe Genetics and Physiology of Life History Traits and Trade-Offs$
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Thomas Flatt and Andreas Heyland

Print publication date: 2011

Print ISBN-13: 9780199568765

Published to Oxford Scholarship Online: December 2013

DOI: 10.1093/acprof:oso/9780199568765.001.0001

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Mechanisms of aging in human populations

Mechanisms of aging in human populations

Chapter 16 Mechanisms of aging in human populations
Mechanisms of Life History Evolution

Maris Kuningas

Rudi G.J. Westendorp

Oxford University Press

Ample evidence from model organisms has indicated that subtle variation in genes can dramatically influence lifespan. The key genes and molecular mechanisms that have been identified so far encode for metabolism, maintenance, and repair mechanisms. This chapter provides an overview of genes and mechanisms that have been shown to regulate lifespan in model organisms. It limits the discussion to those genes that have human homologues, and explores whether and how these influence human lifespan and other life history traits.

Keywords:   lifespan, aging, longevity, senescence, centenarians, candidate genes, genetic variation, environment, humans, life history

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