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Fundamentals and Applications of Magnetic Materials$
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Kannan M. Krishnan

Print publication date: 2016

Print ISBN-13: 9780199570447

Published to Oxford Scholarship Online: December 2016

DOI: 10.1093/acprof:oso/9780199570447.001.0001

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Magnetic Materials in Medicine and Biology

Magnetic Materials in Medicine and Biology

(p.519) 12 Magnetic Materials in Medicine and Biology
Fundamentals and Applications of Magnetic Materials

Kannan M. Krishnan

Oxford University Press

This chapter provides a comprehensive introduction to magnetic materials in medicine and biology with emphasis on nanoscale magnetic particles tailored for imaging, diagnostics, and therapy. Topics covered include magnetic resonance imaging (MRI), magnetic particle imaging (MPI), high gradient magnetic separation, diagnostics using both “on-chip” detection with magnetoresistive sensors and magnetorelaxometry, magnetic fluid hyperthermia, and targeted delivery of drugs and genes (magnetofection). In addition, methods of nanoparticle synthesis, including control of their size, size distribution, shape, surface charge and functionalization, optimization of their magnetic characteristics for each specific application, combined with a discussion of their in vivo biodistribution, paticokinetics and eventual clearance, is presented. We conclude with a discussion of magnetoreception in animals; an exciting area of work in neurobiology aimed at understanding mechanisms of sensing the Earth’s weak geomagnetic field (~30μTμ0−1).

Keywords:   magnetic nanoparticles, in vivo applications, biodistribution, MRI, MPI, magnetic separation, hyperthermia, drug and gene delivery, magnetofection, magnetoreception in animals

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