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Neutron Protein Crystallography – Hydrogen, Protons, and Hydration in Bio-macromolecules - Oxford Scholarship Online
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Neutron Protein Crystallography: Hydrogen, Protons, and Hydration in Bio-macromolecules

Nobuo Niimura and Alberto Podjarny


This book on neutron protein crystallography (NPC) begins with a brief review of the physics of neutrons and neutron diffraction, highlighting the differences between neutron and X-ray diffraction phenomena, and specific features of the interactions between neutrons and bio-macromolecules. Two types of neutron sources—steady-state, reactor neutron sources and pulsed, accelerator-driven neutron sources—are described, along with the different techniques used with each source. A section is devoted to describing the key technologies of neutron detection. In the second part, aspects of the experime ... More

Keywords: neutron protein crystallography, hydrogen, hydration, hydrogen bond, protonation/deprotonation, crystallization phase diagram, large single crystal, H/D exchange, histidine, carboxylate group, neutron image plate

Bibliographic Information

Print publication date: 2011 Print ISBN-13: 9780199578863
Published to Oxford Scholarship Online: May 2011 DOI:10.1093/acprof:oso/9780199578863.001.0001


Affiliations are at time of print publication.

Nobuo Niimura, author
Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Japan

Alberto Podjarny, author
Institute of Genetics and Molecular and Cellular Biology, CNRS, France