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AlcoholScience, Policy and Public Health$
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Peter Boyle, Paolo Boffetta, Albert B. Lowenfels, Harry Burns, Otis Brawley, Witold Zatonski, and Jürgen Rehm

Print publication date: 2013

Print ISBN-13: 9780199655786

Published to Oxford Scholarship Online: May 2013

DOI: 10.1093/acprof:oso/9780199655786.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 June 2021

Upper aerodigestive tumours: mouth, pharynx, larynx, and oesophagus

Upper aerodigestive tumours: mouth, pharynx, larynx, and oesophagus

(p.217) Chapter 25 Upper aerodigestive tumours: mouth, pharynx, larynx, and oesophagus

Mia Hashibe

Binh Y. Goldstein

Lin Cai

Zuo-Feng Zhang

Oxford University Press

This chapter discusses the link between alcohol consumption and upper aerodigestive tumours. Upper aerodigestive tract (UADT) cancers include malignancies of the oral cavity, oropharynx, hypopharynx, larynx, and oesophagus. The major histological type of oral cavity, pharyngeal, and laryngeal cancers is squamous cell carcinoma (SCC), while the proportion of adenocarcinomas to SCC varies by geographic region for oesophageal cancers. While tobacco smoking is the most important risk factor for SCCs of the UADT, studies focusing on never-smokers have demonstrated an independent effect of alcohol. Consuming 50g of alcohol per day may increase the risk of oral cavity and pharyngeal cancers by approximately threefold, the risk of laryngeal cancer by twofold relative to non-drinkers, and the risk of SCC of the oesophagus by fivefold. In contrast, alcohol drinking was not strongly associated with oesophageal adenocarcinomas.

Keywords:   alcohol consumption, cancer risk, alcohol intake, upper aerodigestive tract cancers

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