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AlcoholScience, Policy and Public Health$
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Peter Boyle, Paolo Boffetta, Albert B. Lowenfels, Harry Burns, Otis Brawley, Witold Zatonski, and Jürgen Rehm

Print publication date: 2013

Print ISBN-13: 9780199655786

Published to Oxford Scholarship Online: May 2013

DOI: 10.1093/acprof:oso/9780199655786.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 23 June 2021

Bladder and genitourinary tumours

Bladder and genitourinary tumours

(p.241) Chapter 29 Bladder and genitourinary tumours

Claudio Pelucchi

Carlotta Galeone

Oxford University Press

This chapter reviews studies on the link between alcohol consumption and the genitourinary cancers. No material association emerged between alcohol drinking and bladder cancer in a revision of about forty epidemiological investigations. This conclusion is further supported by two meta-analyses that recently provided definite quantitative evidence on the issue. Results were somewhat inconsistent between studies, possibly because of different drinking patterns and correlates — mainly tobacco smoking — among different populations. However, residual confounding by smoking might explain the moderate increase in risk of bladder cancer reported in some studies. Increasing evidence from large cohort studies indicates a protective role of moderate alcohol drinking on kidney cancer. This has been attributed to the effects of alcohol on insulin sensitivity, or through a role of fluid and/or antioxidants intake contained in alcoholic drinks. The risk appears to level-off in heavy drinkers. Results for prostate cancer are somewhat heterogeneous. Overall, the available evidence suggests no meaningful role of alcohol consumption.

Keywords:   alcohol consumption, alcohol intake, cancer risk, genitourinary cancers, bladder cancer, kidney cancer, prostate cancer

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