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A Life Course Approach to Healthy Ageing$
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Diana Kuh, Rachel Cooper, Rebecca Hardy, Marcus Richards, and Yoav Ben-Shlomo

Print publication date: 2013

Print ISBN-13: 9780199656516

Published to Oxford Scholarship Online: January 2014

DOI: 10.1093/acprof:oso/9780199656516.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 02 December 2021

Vascular and metabolic function across the life course

Vascular and metabolic function across the life course

(p.146) Chapter 11 Vascular and metabolic function across the life course
A Life Course Approach to Healthy Ageing

Debbie A Lawlor

Rebecca Hardy

Oxford University Press

The pathophysiological process of atherosclerosis, which ultimately leads to cardiovascular disease, begins in childhood and young adulthood. This chapter describes the life course trajectories in blood pressure, lipids, glucose, insulin, and non-invasive assessments of vascular structure and function and, explores differences between males and females and by ethnic group. It reviews evidence regarding the associations of pre-adult risk factors with these trajectories, explores whether puberty, pregnancy, and the perimenopause are key periods when the trajectories show distinct changes, and describes how changes in the trajectories relate to cardiovascular disease. Higher blood pressure, low density lipoprotein cholesterol, and fasting glucose in adolescence and early adulthood are associated with adverse cardiometabolic events in older age. Despite cohort studies in children and adults often repeatedly measuring cardiometabolic markers, few have appropriately modelled change with age in relation to risk factors, or explored how different patterns of change relate to future disease risk.

Keywords:   blood pressure, lipids, glucose, insulin, vascular function, ethnic differences, gender differences, puberty, pregnancy, perimenopause

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