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Handbook of Cannabis$
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Roger Pertwee

Print publication date: 2014

Print ISBN-13: 9780199662685

Published to Oxford Scholarship Online: January 2015

DOI: 10.1093/acprof:oso/9780199662685.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 April 2021

Non-Phytocannabinoid Constituents of Cannabis and Herbal Synergy

Non-Phytocannabinoid Constituents of Cannabis and Herbal Synergy

(p.280) Chapter 15 Non-Phytocannabinoid Constituents of Cannabis and Herbal Synergy
Handbook of Cannabis

John M. McPartland

Ethan B. Russo

Oxford University Press

This chapter introduces the concepts of therapeutic polypharmacy and synergy, and their applications to herbal medicines. Chemists and pharmacologists working with cannabis have pioneered research on these concepts for over a century. Therapeutic synergy between phytocannabinoids, such as Δ‎9-THC and CBD, is detailed in Chapters 6 and 7. Less research has focused upon the therapeutic synergy generated by terpenoids, flavonoids, and other constituents of cannabis. The chapter reviews studies demonstrating how these constituents enhance the beneficial effects of THC and CBD, and reduce the side effects of THC. Non-phytocannabinoid constituents also impact upon the endocannabinoid system, which includes receptors, ligands, and ligand-metabolizing enzymes. These interactions are pharmacodynamic and pharmacokinetic, and in many cases the mechanism has not been identified.

Keywords:   flavonoid, herbal medicine, isobolographic analysis, therapeutic polypharmacy, synergy, terpenoid, David Hooper, David Prain, Walter Siegried Loewe

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