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Handbook of Cannabis$
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Roger Pertwee

Print publication date: 2014

Print ISBN-13: 9780199662685

Published to Oxford Scholarship Online: January 2015

DOI: 10.1093/acprof:oso/9780199662685.001.0001

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Phytocannabinoids as Novel Therapeutic Agents for Sleep Disorders

Phytocannabinoids as Novel Therapeutic Agents for Sleep Disorders

(p.538) Chapter 29 Phytocannabinoids as Novel Therapeutic Agents for Sleep Disorders
Handbook of Cannabis

Eric Murillo-Rodríguez

Lisa Aguilar-Turton

Stephanie Mijangos-Moreno

Andrea Sarro-Ramírez

Óscar Arias-Carrión

Oxford University Press

Sleep is a universal phenomenon that occurs in every species studied so far. A normal sleep period fluctuates in a regular cycle of two basic forms: slow wave sleep (SWS) and rapid eye movement (REM) sleep. The sleep–wake cycle is modulated by diverse brain circuits and neuromodulators as well as by several endogenous and exogenous molecules, including cannabinoids. This chapter describes the effects of certain cannabis-derived and synthetic cannabinoids on sleep. Additionally, it provides an overview of current knowledge about potential uses of natural or synthetic cannabinoids for the treatment of sleep disorders.

Keywords:   phytocannabinoids, Cannabis sativa, sleep disorders, insomnia, somnolence

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