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Handbook of Cannabis$
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Roger Pertwee

Print publication date: 2014

Print ISBN-13: 9780199662685

Published to Oxford Scholarship Online: January 2015

DOI: 10.1093/acprof:oso/9780199662685.001.0001

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Cardiovascular, Metabolic, Liver, Kidney, and Inflammatory Disorders

Cardiovascular, Metabolic, Liver, Kidney, and Inflammatory Disorders

(p.564) Chapter 31 Cardiovascular, Metabolic, Liver, Kidney, and Inflammatory Disorders
Handbook of Cannabis

Pál Pacher

George Kunos

Oxford University Press

There is increasing evidence that phytocannabinoids may exert beneficial effects in inflammatory, cardiovascular, metabolic, liver, and kidney disorders. This chapter briefly discusses the potential therapeutic targets and applications of phytocannabinoids, primarily based on in vivo studies. The focus is on the therapeutic effects of cannabidiol (CBD), the most abundant non-psychotropic constituent of Cannabis sativa (marijuana), and on the therapeutic and undesirable effects of Δ‎9-tetrahydrocannabinol (THC), the psychoactive constituent of marijuana initially thought to be responsible for the whole spectrum of the biological effects of marijuana. The therapeutic potential of Δ‎9-tetrahydrocannabivarin (Δ‎9THCV), a natural cannabinoid found in marijuana plant, and (E)-β‎-caryophyllene (BCP; FDA-approved food additive), a natural sesquiterpene found in many essential oils of spice including in Cannabis sativa, will also be highlighted based on several recent studies.

Keywords:   phytocannabinoids, Δ9-tetrahydrocannabivarin, Δ9-tetrahydrocannabinol, cannabidiol, (E)-β-caryophyllene, inflammatory, cardiovascular, metabolic, liver, kidney

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