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Teaching EpidemiologyA guide for teachers in epidemiology, public health and clinical medicine$
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Jørn Olsen, Naomi Greene, Rodolfo Saracci, and Dimitrios Trichopoulos

Print publication date: 2015

Print ISBN-13: 9780199685004

Published to Oxford Scholarship Online: June 2015

DOI: 10.1093/acprof:oso/9780199685004.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 25 November 2020

Pharmacoepidemiology

Pharmacoepidemiology

Chapter:
(p.138) Chapter 10 Pharmacoepidemiology
Source:
Teaching Epidemiology
Author(s):

Susan Jick

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199685004.003.0010

This chapter provides an approach to teaching techniques for conducting observational drug safety studies, with a focus on describing the most important components of good research methodology: defining exposure, outcome, and controlling for confounding. Since the area of drug safety covers all drugs and most clinical diagnoses, it is critical to carefully consider every drug disease relationship when designing a study to evaluate the association between the two. Drugs are taken short term, chronically, and intermittently. Outcomes can be acute or delayed. These factors dictate how exposure and outcome are defined. Confounding by indication is a constant concern in pharmacoepidemiology as are other important confounders. This chapter discusses methods for controlling for confounding in the study design. Examples and assignments are presented to reinforce the course material. Use of large administrative and electronic medical record databases and their importance to pharmacoepidemiology are also described and discussed at length.

Keywords:   pharmacoepidemiology, exposure, confounding by indication, medical record databases, drug safety

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