It is comforting to know that the response to illness can be positive. This chapter summarises practical, psychological and spiritual ways towards this end. Many people feel lonely in their suffering and find professional or peer support restorative. Attempting to find something meaningful to fill the day, people can learn new skills and crafts or revive old or much loved occupations. Writing and artwork can help to have conversations with oneself through which a bearable meaning for the loss can be found. Some people receive nourishment and succour from the simplest things. They can sit and watch a bird, listen to music, pray or meditate and to them that is life giving. Intimate relationships can be a haven of mutual trust and loyalty and new patterns of sharing life can be invented. At the heart of coping with the challenge of illness is acceptance of it as a reality. This is not very easy and it is not a constant state.