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Genetics of Psychological Well-BeingThe role of heritability and genetics in positive psychology$
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Michael Pluess

Print publication date: 2015

Print ISBN-13: 9780199686674

Published to Oxford Scholarship Online: August 2015

DOI: 10.1093/acprof:oso/9780199686674.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 26 July 2021

Molecular genetics of psychological well-being

Molecular genetics of psychological well-being

(p.163) Chapter 10 Molecular genetics of psychological well-being
Genetics of Psychological Well-Being

Meike Bartels

Bart M. L. Baselmans

Oxford University Press

Psychological well-being constitutes a growing area of research in behavioral genetics. Quantitative behavioral genetic studies have revealed that a substantial part (~40%) of the variation in subjective well-being (SWB) could be attributed to genetic influences, supporting the scientific effort to identify genomic regions associated with well-being. However, this field is still in its infancy and the few attempts are showing mixed results. Therefore, this chapter provides an overview of the existing molecular genetic studies involving psychological well-being. The different methodological approaches, such as linkage and association analysis, are discussed for their strengths and limitations as well as their opportunities. In general, most studies were likely underpowered to detect genetic effects associated with well-being, a phenotype that is expected to be influenced by many genes with small effect sizes. However, a GWAS (>100K) is in the pipeline and will appear in the near future.

Keywords:   psychological well-being, molecular genetics, linkage analysis, association analysis, genome-wide association

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