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Genetics of Psychological Well-BeingThe role of heritability and genetics in positive psychology$
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Michael Pluess

Print publication date: 2015

Print ISBN-13: 9780199686674

Published to Oxford Scholarship Online: August 2015

DOI: 10.1093/acprof:oso/9780199686674.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 03 August 2021

Molecular genetics of resilience

Molecular genetics of resilience

(p.177) Chapter 11 Molecular genetics of resilience
Genetics of Psychological Well-Being

Sierra Clifford

Kathryn Lemery-Chalfant

Oxford University Press

Resilience, or the maintenance of positive functioning in the face of stressful conditions, is a process which can be observed across social and biological levels throughout the course of development. This chapter focuses on the molecular genetics of resilience and gene–environment interaction within the diathesis–stress framework. It first describes the ways in which genes might contribute to resilience, including potential mediating processes linking genes to resilience. It also discusses methodological issues including phenotypic heterogeneity, the need for greater sensitivity to developmental concerns, and individual characteristics which may moderate genetic influences on resilience, and then reviews the literature on molecular gene–environment interaction, concentrating on a selection of genes that are implicated in resilience processes. It is suggested that future research should specify the level at which gene–environment interaction occurs, identify and investigate the underlying social and biological mechanisms, and move toward a biological systems-focused approach.

Keywords:   resilience, molecular genetics, gene–environment interaction, diathesis–stress, phenotypic heterogeneity

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