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Engineering the Next Revolution in NeuroscienceThe New Science of Experiment Planning$
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Alcino J. Silva, Anthony Landreth, and John Bickle

Print publication date: 2013

Print ISBN-13: 9780199731756

Published to Oxford Scholarship Online: January 2014

DOI: 10.1093/acprof:oso/9780199731756.001.0001

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The Power of Convergence

The Power of Convergence

(p.42) [4] The Power of Convergence
Engineering the Next Revolution in Neuroscience

Alcino J. Silva

Anthony Landreth

John Bickle

Oxford University Press

In molecular and cellular cognition, there are three types of experiments that can be carried out to test whether A causes B (A→B): The magnitude of A can either be (1) increased or (2) decreased, and the impact on B measured, or (3) A and B can be measured without being intentionally altered to determine if they co-vary. A distinctive pattern of convergent evidence, referred to as the Convergent 3, emerges when these three kinds of experiments are consistent with a single hypothesis. In this chapter, the Convergent 3 Integration analysis is illustrated in action with learning and memory experiments focusing on the role of calmodulin kinase II in plasticity and learning.

Keywords:   Experiment, causation, hippocampus, learning, memory, long-term potentiation, calmodulin kinase II

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