- Title Pages
- Dedication
- Acknowledgments
- Preface
- Epigraph
-
1 Introduction -
2 The Language of Clinical Trials -
3 The Recipe for Trials -
4 The Stages of Trials -
5 The Anatomy of Trials -
6 Authorship and Credits -
7 The Nature of Trials -
8 The Ethics of Trials -
9 Regulation of Trials -
10 Research Misconduct -
11 Myths Regarding Trials -
12 Tricks of the Trade from a Cynic -
13 Reading Between the Lines, or How to Read a Journal Article -
14 Critics and Criticisms -
15 What to Make of Results -
16 Biostatistics 101 -
17 Subgroup Analysis vs. Data Dredging -
18 Meta-analyses and Systematic Reviews -
19 Re-Search -
20 Shopping for a Trial? -
21 Readings -
22 Clinical Trials and Our Health -
23 Final Exam -
24 Last Words -
Appendix A The Mother Test for Designers of Trials -
Appendix B Rating Index for Clinical Trials -
Appendix C A Patient’s Guide for Deciding Whether to Enroll in a Randomized Trial -
Appendix D Abbreviations - References
- Author Index
- Subject Index
Introduction
Introduction
- Chapter:
- (p.1) 1 Introduction
- Source:
- An Insider’s Guide to Clinical Trials
- Author(s):
Curtis L. Meinert
- Publisher:
- Oxford University Press
This introductory chapter begins with a brief description of the origins of the term clinical trial and the concept of randomization. It then details the development of modern-day clinical trials, pioneered by Sir Austin Bradford Hill. His 1962 book Statistical Methods in Clinical and Preventive Medicine represented an important milestone in the field of clinical trials. This is followed by a discussion of single- vs. multicenter clinical trial and the classification of trials by design.
Keywords: clinical trials, randomization, Austin Bradford Hill, classification
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- Title Pages
- Dedication
- Acknowledgments
- Preface
- Epigraph
-
1 Introduction -
2 The Language of Clinical Trials -
3 The Recipe for Trials -
4 The Stages of Trials -
5 The Anatomy of Trials -
6 Authorship and Credits -
7 The Nature of Trials -
8 The Ethics of Trials -
9 Regulation of Trials -
10 Research Misconduct -
11 Myths Regarding Trials -
12 Tricks of the Trade from a Cynic -
13 Reading Between the Lines, or How to Read a Journal Article -
14 Critics and Criticisms -
15 What to Make of Results -
16 Biostatistics 101 -
17 Subgroup Analysis vs. Data Dredging -
18 Meta-analyses and Systematic Reviews -
19 Re-Search -
20 Shopping for a Trial? -
21 Readings -
22 Clinical Trials and Our Health -
23 Final Exam -
24 Last Words -
Appendix A The Mother Test for Designers of Trials -
Appendix B Rating Index for Clinical Trials -
Appendix C A Patient’s Guide for Deciding Whether to Enroll in a Randomized Trial -
Appendix D Abbreviations - References
- Author Index
- Subject Index
