- Title Pages
- Dedication
- Acknowledgments
- Preface
- Epigraph
-
1 Introduction -
2 The Language of Clinical Trials -
3 The Recipe for Trials -
4 The Stages of Trials -
5 The Anatomy of Trials -
6 Authorship and Credits -
7 The Nature of Trials -
8 The Ethics of Trials -
9 Regulation of Trials -
10 Research Misconduct -
11 Myths Regarding Trials -
12 Tricks of the Trade from a Cynic -
13 Reading Between the Lines, or How to Read a Journal Article -
14 Critics and Criticisms -
15 What to Make of Results -
16 Biostatistics 101 -
17 Subgroup Analysis vs. Data Dredging -
18 Meta-analyses and Systematic Reviews -
19 Re-Search -
20 Shopping for a Trial? -
21 Readings -
22 Clinical Trials and Our Health -
23 Final Exam -
24 Last Words -
Appendix A The Mother Test for Designers of Trials -
Appendix B Rating Index for Clinical Trials -
Appendix C A Patient’s Guide for Deciding Whether to Enroll in a Randomized Trial -
Appendix D Abbreviations - References
- Author Index
- Subject Index
Meta-analyses and Systematic Reviews
Meta-analyses and Systematic Reviews
- Chapter:
- (p.159) 18 Meta-analyses and Systematic Reviews
- Source:
- An Insider’s Guide to Clinical Trials
- Author(s):
Curtis L. Meinert
- Publisher:
- Oxford University Press
A meta-analysis is an analysis using either aggregate results or individual patient data from published trials. It is done to provide a more comprehensive and informative view of results than is possible with any single trial. A related activity is systematic review. Such reviews, as applied to trials, typically involve efforts to identify all trials relevant to the question of interest, whether published or not, critical appraisals of the trials, and ultimately, a conclusion as to the weight of evidence for or against the treatment. Such reviews may or may not involve formal meta-analyses. Most meta-analyses, in contrast with systematic reviews, are based exclusively on published trials.
Keywords: clinical trial, meta-analysis, systematic review, published trials, critical appraisals
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- Title Pages
- Dedication
- Acknowledgments
- Preface
- Epigraph
-
1 Introduction -
2 The Language of Clinical Trials -
3 The Recipe for Trials -
4 The Stages of Trials -
5 The Anatomy of Trials -
6 Authorship and Credits -
7 The Nature of Trials -
8 The Ethics of Trials -
9 Regulation of Trials -
10 Research Misconduct -
11 Myths Regarding Trials -
12 Tricks of the Trade from a Cynic -
13 Reading Between the Lines, or How to Read a Journal Article -
14 Critics and Criticisms -
15 What to Make of Results -
16 Biostatistics 101 -
17 Subgroup Analysis vs. Data Dredging -
18 Meta-analyses and Systematic Reviews -
19 Re-Search -
20 Shopping for a Trial? -
21 Readings -
22 Clinical Trials and Our Health -
23 Final Exam -
24 Last Words -
Appendix A The Mother Test for Designers of Trials -
Appendix B Rating Index for Clinical Trials -
Appendix C A Patient’s Guide for Deciding Whether to Enroll in a Randomized Trial -
Appendix D Abbreviations - References
- Author Index
- Subject Index
