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An Insider’s Guide to Clinical Trials$
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Curtis L Meinert

Print publication date: 2011

Print ISBN-13: 9780199742967

Published to Oxford Scholarship Online: September 2011

DOI: 10.1093/acprof:oso/9780199742967.001.0001

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Meta-analyses and Systematic Reviews

Meta-analyses and Systematic Reviews

(p.159) 18 Meta-analyses and Systematic Reviews
An Insider’s Guide to Clinical Trials

Curtis L. Meinert

Oxford University Press

A meta-analysis is an analysis using either aggregate results or individual patient data from published trials. It is done to provide a more comprehensive and informative view of results than is possible with any single trial. A related activity is systematic review. Such reviews, as applied to trials, typically involve efforts to identify all trials relevant to the question of interest, whether published or not, critical appraisals of the trials, and ultimately, a conclusion as to the weight of evidence for or against the treatment. Such reviews may or may not involve formal meta-analyses. Most meta-analyses, in contrast with systematic reviews, are based exclusively on published trials.

Keywords:   clinical trial, meta-analysis, systematic review, published trials, critical appraisals

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