This chapter examines the history of the chemical pesticide DDT after the United States banned its use in 1972. It explores how U.S. policy makers, environmental activists, and chemical corporations shaped federal pesticide regulation throughout the 1970s. During this period, the global marketplace for DDT and other chemical pesticides exploded, as domestic and foreign chemical corporations marketed their products around the world. The dramatic increase of pesticide consumption worldwide called into question the limits of state power. This chapter considers the regulatory limits of the nation-state and its impact on the global environment by situating the history of U.S. pesticide regulation in an international context.