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Brain Aromatase, Estrogens, and Behavior$
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Jacques Balthazart and Gregory Ball

Print publication date: 2012

Print ISBN-13: 9780199841196

Published to Oxford Scholarship Online: January 2013

DOI: 10.1093/acprof:oso/9780199841196.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 13 April 2021

Testosterone Metabolism in Reptiles

Testosterone Metabolism in Reptiles

(p.221) Chapter 12 Testosterone Metabolism in Reptiles
Brain Aromatase, Estrogens, and Behavior

Rachel E. Cohen

Juli Wade

Oxford University Press

In the brain, testosterone (T) can be metabolized into estradiol via the action of the aromatase enzyme, and into 5α-dihydrotestosterone via the action of the 5α-reductase (5αR) enzyme. This chapter discusses aromatase and 5αR in reptiles, with a focus on green anole lizards. The chapter examines the role of aromatase and 5αR on reproductive behavior in this species. Next the chapter examines the whole brain activity of aromatase and 5αR, as well as the mRNA distribution of these enzymes in three brain areas critical for reproduction: the preoptic area, amygdala, and ventromedial hypothalamus. Finally the chapter discusses the expression of these enzymes in juvenile anoles. Overall, the experiments presented here highlight the importance of comparative work and lay groundwork for future research that will ascertain the role of these enzymes in anoles and the extent of their regulation by T.

Keywords:   amygdala, Anolis carolinensis, aromatase, 5α-reductase 1, 5α-reductase 2, green anole lizard, preoptic area, ventromedial hypothalamus

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