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Brain Aromatase, Estrogens, and Behavior$
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Jacques Balthazart and Gregory Ball

Print publication date: 2012

Print ISBN-13: 9780199841196

Published to Oxford Scholarship Online: January 2013

DOI: 10.1093/acprof:oso/9780199841196.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 13 April 2021

Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches

Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches

(p.13) Chapter 2 Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches
Brain Aromatase, Estrogens, and Behavior

Gloria V. Callard

Sarah R. Greytak

Apolonia Novillo

Kellie A. Cotter

Rebecca K. Meyer

Oxford University Press

The ability to convert androgens to estrogens is an ancient and highly conserved characteristic of the vertebrate brain but is lacking in amphioxus and all other invertebrates, indicating that a functional form of the enzyme first evolved in the brain of a basal jawed vertebrate (∼400 million years ago, mya), not long after its origin in the urogenital ridge of a common vertebrate ancestor (∼500 mya). This chapter reviews the history of fishes in brain aromatase research, specifically, their utility as laboratory models for advancing our understanding of the basic biology of neural aromatase; and the applicability of the predominant brain form of aromatase in fishes as a biomarker of general reproductive health and an indicator of pollutants in the natural environment.

Keywords:   aromatases, CYP19A, CYP19B, estrogen synthesis, fishes

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