- Title Pages
- Contributors
- Introduction
- Chapter 1 The Aromatization Hypothesis and the Discovery of Estrogen Synthesis by Brain Cells
- Chapter 2 Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches
- Chapter 3 The Distribution and Regulation of Aromatase in the Mammalian Brain: from Mice to Monkeys
- Chapter 4 Multiple Forms of Aromatase in Suiformes: Tissue Distribution, Regulation, and Functional Significance
- Chapter 5 Regional Distribution of Aromatase in the Human Brain
- Chapter 6 Neuroanatomical Distribution of Aromatase in Birds: Cellular and Subcellular Analyses
- Chapter 7 Expression, Regulation, and Potential Functions of Aromatase in Radial Glial Cells of the Fish Brain
- Chapter 8 Molecular Mechanisms Controlling Brain Aromatase Expression
- Chapter 9 The Aromatization Hypothesis, 1970–1990
- Chapter 10 Aromatase and Behavior: Concepts Gained from Studies of Aromatase in the Avian Brain
- Chapter 11 Brain Aromatase and Territorial Aggression Across the Seasons in Male Song Sparrows
- Chapter 12 Testosterone Metabolism in Reptiles
- Chapter 13 Aromatase, Low Temperature Dormancy, and Reproduction in the Red-Sided Garter Snake
- Chapter 14 Differential Actions of Estrogens in the Male and Female Brain: A Case for Sex-Specific Medicines
- Chapter 15 A Historical and Personal Perspective on the Aromatization Revolution: Steinach Confirmed<sup>1</sup>
- Chapter 16 Aromatase and Sexual Differentiation of the Rodent Brain: The Old, the New, and the Unexpected
- Chapter 17 Aromatase and Sexual Differentiation: Lessons from the Aromatase and Alpha-Fetoprotein Knockout Mice
- Chapter 18 Aromatase, Estrogens, and Differentiation of Sexual Behavior and Partner Preference in Birds
- Chapter 19 Brain Aromatase and Neuroprotection in Mammals
- Chapter 20 Inducible Aromatase in Astroglia: Protection and Recovery from Neural Perturbation in Birds
- Chapter 21 Photoperiodic Regulation of Estrogen-Dependent Aggression
- Chapter 22 Cellular Mechanisms Controlling Rapid Changes in Brain Aromatase Activity
- Chapter 23 Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail
- Chapter 24 Modulation of Central Auditory Processing by a Brain-Generated Estrogen: Rapid Effects on Neural Coding, Discrimination, and Behavior
- Chapter 25 Acute Synthesis and Action of Estrogens in Communication Circuits
- Chapter 26 Rapid Effects of Estradiol on Behavioral and Physiological Responses Related to Reproduction in Male Goldfish
- Chapter 27 Concluding Statements and Current Challenges
- Index
Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail
Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail
- Chapter:
- (p.438) Chapter 23 Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail
- Source:
- Brain Aromatase, Estrogens, and Behavior
- Author(s):
Charlotte A. Cornil
Molly J. Dickens
Gregory F. Ball
Jacques Balthazart
- Publisher:
- Oxford University Press
Brain aromatase activity is largely controlled by steroids via modulation of the transcription of the aromatase gene that regulates the amount of available enzyme. Recent evidence, however, indicates that the kinetics of aromatase activity is also rapidly modulated by conformational changes of the protein. This discovery shifted the interest of research on aromatase towards much shorter physiological time scales and suggested that a mechanism is in place to allow changes in local estradiol concentration in a time frame compatible with the activation of fast non-genomic actions of estrogens. The present chapter provides evidence that this mechanism, discovered in vitro, is functionally significant in vivo. This chapter first reviews studies that identified rapid modulations of aromatase activity following social interactions or exposure to acute stress. Then, this chapter will focus on the implications of such rapid changes of local estrogens availability for the control of reproduction.
Keywords: enzymatic activity, Japanese quail, nongenomic effects, sexual behavior, stress
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- Title Pages
- Contributors
- Introduction
- Chapter 1 The Aromatization Hypothesis and the Discovery of Estrogen Synthesis by Brain Cells
- Chapter 2 Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches
- Chapter 3 The Distribution and Regulation of Aromatase in the Mammalian Brain: from Mice to Monkeys
- Chapter 4 Multiple Forms of Aromatase in Suiformes: Tissue Distribution, Regulation, and Functional Significance
- Chapter 5 Regional Distribution of Aromatase in the Human Brain
- Chapter 6 Neuroanatomical Distribution of Aromatase in Birds: Cellular and Subcellular Analyses
- Chapter 7 Expression, Regulation, and Potential Functions of Aromatase in Radial Glial Cells of the Fish Brain
- Chapter 8 Molecular Mechanisms Controlling Brain Aromatase Expression
- Chapter 9 The Aromatization Hypothesis, 1970–1990
- Chapter 10 Aromatase and Behavior: Concepts Gained from Studies of Aromatase in the Avian Brain
- Chapter 11 Brain Aromatase and Territorial Aggression Across the Seasons in Male Song Sparrows
- Chapter 12 Testosterone Metabolism in Reptiles
- Chapter 13 Aromatase, Low Temperature Dormancy, and Reproduction in the Red-Sided Garter Snake
- Chapter 14 Differential Actions of Estrogens in the Male and Female Brain: A Case for Sex-Specific Medicines
- Chapter 15 A Historical and Personal Perspective on the Aromatization Revolution: Steinach Confirmed<sup>1</sup>
- Chapter 16 Aromatase and Sexual Differentiation of the Rodent Brain: The Old, the New, and the Unexpected
- Chapter 17 Aromatase and Sexual Differentiation: Lessons from the Aromatase and Alpha-Fetoprotein Knockout Mice
- Chapter 18 Aromatase, Estrogens, and Differentiation of Sexual Behavior and Partner Preference in Birds
- Chapter 19 Brain Aromatase and Neuroprotection in Mammals
- Chapter 20 Inducible Aromatase in Astroglia: Protection and Recovery from Neural Perturbation in Birds
- Chapter 21 Photoperiodic Regulation of Estrogen-Dependent Aggression
- Chapter 22 Cellular Mechanisms Controlling Rapid Changes in Brain Aromatase Activity
- Chapter 23 Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail
- Chapter 24 Modulation of Central Auditory Processing by a Brain-Generated Estrogen: Rapid Effects on Neural Coding, Discrimination, and Behavior
- Chapter 25 Acute Synthesis and Action of Estrogens in Communication Circuits
- Chapter 26 Rapid Effects of Estradiol on Behavioral and Physiological Responses Related to Reproduction in Male Goldfish
- Chapter 27 Concluding Statements and Current Challenges
- Index