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Brain Aromatase, Estrogens, and Behavior$
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Jacques Balthazart and Gregory Ball

Print publication date: 2012

Print ISBN-13: 9780199841196

Published to Oxford Scholarship Online: January 2013

DOI: 10.1093/acprof:oso/9780199841196.001.0001

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Molecular Mechanisms Controlling Brain Aromatase Expression

Molecular Mechanisms Controlling Brain Aromatase Expression

(p.138) Chapter 8 Molecular Mechanisms Controlling Brain Aromatase Expression
Brain Aromatase, Estrogens, and Behavior

Nobuhiro Harada

Shin-ichiro Honda

Oxford University Press

Aromatase is expressed not only in gonadal tissues but also in nongonadal tissues including the brain, and participates in various tissue-specific functions through local production of estrogens. To control diverse physiological functions in various tissues, aromatase has a unique gene structure with multiple exons 1 and promoters that are used in a tissue-specific manner. The transcriptional regulation of aromatase expression is mediated by binding of tissue-specific transcription factors or hormones to their responsive elements on each promoter to activate or repress the transcriptional machinery. Possible regulatory factors/hormones, transcription factors, and DNA responsive elements involved in the tissue-specific expression of aromatase are reviewed in this chapter.

Keywords:   alternative splicing, DNase footprinting, gel shift assay, hypothalamus, multiple exon 1 variants, perinatal period, promoter activity, responsive element, tissue-specific expression, transcription factor

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