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Brain Aromatase, Estrogens, and Behavior - Oxford Scholarship Online
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Brain Aromatase, Estrogens, and Behavior

Jacques Balthazart and Gregory Ball

Abstract

Aromatase—or estrogen, as it is commonly known—is present in the brain and has been the subject of much recent research, not only with regard to menopause and the dwindling supply of estrogen and its impact on cognition, but the role estrogen in aging and plasticity in the brain. This book provides a review of what is known about aromatase and its distribution and regulation in the brain, and its many effects on behavior. The volume covers research on mammals (from rats to monkeys), as well as work done on birds, reptiles and amphibians, and fishes. Topics range from behavioral effects (genomi ... More

Keywords: aromatase, estrogen, menopause, cognition, behavior, sexual differentiation, brain repair, sensory processing

Bibliographic Information

Print publication date: 2012 Print ISBN-13: 9780199841196
Published to Oxford Scholarship Online: January 2013 DOI:10.1093/acprof:oso/9780199841196.001.0001

Authors

Affiliations are at time of print publication.

Jacques Balthazart, editor
University of Liege, Belgium

Gregory Ball, editor
Johns Hopkins University

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Contents

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Front Matter

Title Pages

Contributors

Introduction

Part I Historical Origins and Conceptual Basis of the Field

Chapter 1 The Aromatization Hypothesis and the Discovery of Estrogen Synthesis by Brain Cells

Frederick Naftolin

Part II Aromatase, Its Brain Distribution and Regulation

Chapter 2 Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches

Gloria V. Callard, Sarah R. Greytak, Apolonia Novillo, Kellie A. Cotter, and Rebecca K. Meyer

Chapter 3 The Distribution and Regulation of Aromatase in the Mammalian Brain: from Mice to Monkeys

Charles E. Roselli

Chapter 4 Multiple Forms of Aromatase in Suiformes: Tissue Distribution, Regulation, and Functional Significance

Alan Conley, Veronica N. Orr, Brian C. Trainor, Trish Berger, and Austin Hughes

Chapter 5 Regional Distribution of Aromatase in the Human Brain

Anat Biegon, Joanna Fowler, Sunny Kim, Jean Logan, Deborah Pareto, and Gene-Jack Wang

Chapter 6 Neuroanatomical Distribution of Aromatase in Birds: Cellular and Subcellular Analyses

Colin J. Saldanha, Luke Remage-Healey, and Barney A. Schlinger

Chapter 7 Expression, Regulation, and Potential Functions of Aromatase in Radial Glial Cells of the Fish Brain

Elisabeth Pellegrini, Colette Vaillant, Nicolas Diotel, Pascal Benquet, François Brion, and Olivier Kah

Chapter 8 Molecular Mechanisms Controlling Brain Aromatase Expression

Nobuhiro Harada, and Shin-ichiro Honda

Part III Behavioral (Genomic) Effects of Locally Produced Estrogen in the Brain

Chapter 9 The Aromatization Hypothesis, 1970–1990

Lynwood G. Clemens

Chapter 10 Aromatase and Behavior: Concepts Gained from Studies of Aromatase in the Avian Brain

Barney Schlinger, and Jacques Balthazart

Chapter 11 Brain Aromatase and Territorial Aggression Across the Seasons in Male Song Sparrows

Sarah A. Heimovics, H. Bobby Fokidis, and Kiran K. Soma

Chapter 12 Testosterone Metabolism in Reptiles

Rachel E. Cohen, and Juli Wade

Chapter 13 Aromatase, Low Temperature Dormancy, and Reproduction in the Red-Sided Garter Snake

Randolph W. Krohmer

Chapter 14 Differential Actions of Estrogens in the Male and Female Brain: A Case for Sex-Specific Medicines

Glenda E. Gillies

Part IV Aromatase and Sexual Differentiation

Chapter 15 A Historical and Personal Perspective on the Aromatization Revolution: Steinach Confirmed1

Per Södersten

Chapter 16 Aromatase and Sexual Differentiation of the Rodent Brain: The Old, the New, and the Unexpected

Margaret M. McCarthy, Christopher L. Wright, and Anne T. M. Konkle

Chapter 17 Aromatase and Sexual Differentiation: Lessons from the Aromatase and Alpha-Fetoprotein Knockout Mice

Julie Bakker

Chapter 18 Aromatase, Estrogens, and Differentiation of Sexual Behavior and Partner Preference in Birds

Elizabeth Adkins-Regan

Part V Aromatase and Brain Protection or Repair

Chapter 19 Brain Aromatase and Neuroprotection in Mammals

Iñigo Azcoitia, Maria Angeles Arevalo, and Luis Miguel Garcia-Segura

Chapter 20 Inducible Aromatase in Astroglia: Protection and Recovery from Neural Perturbation in Birds

Kelli A. Duncan, and Colin J. Saldanha

Part VI Rapid Changes in Aromatase Activity & Rapid Effects of Estrogens

Chapter 21 Photoperiodic Regulation of Estrogen-Dependent Aggression

Sarah A. Laredo, and Brian C. Trainor

Chapter 22 Cellular Mechanisms Controlling Rapid Changes in Brain Aromatase Activity

Thierry D. Charlier, Charlotte A. Cornil, Gregory F. Ball, and Jacques Balthazart

Chapter 23 Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail

Charlotte A. Cornil, Molly J. Dickens, Gregory F. Ball, and Jacques Balthazart

Chapter 24 Modulation of Central Auditory Processing by a Brain-Generated Estrogen: Rapid Effects on Neural Coding, Discrimination, and Behavior

Liisa A. Tremere, and Raphael Pinaud

Chapter 25 Acute Synthesis and Action of Estrogens in Communication Circuits

Luke Remage-Healey

Chapter 26 Rapid Effects of Estradiol on Behavioral and Physiological Responses Related to Reproduction in Male Goldfish

Richmond R. Thompson, and Lisa A. Mangiamele

Chapter 27 Concluding Statements and Current Challenges

Jacques Balthazart, and Gregory F. Ball

End Matter

Index