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Endocrine Disruptors, Brain, and Behavior$
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Heather B. Patisaul and Scott M. Belcher

Print publication date: 2017

Print ISBN-13: 9780199935734

Published to Oxford Scholarship Online: May 2017

DOI: 10.1093/acprof:oso/9780199935734.001.0001

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Landmark Endocrine-Disrupting Compounds of the Past and Present

Landmark Endocrine-Disrupting Compounds of the Past and Present

Chapter:
(p.51) Chapter 3 Landmark Endocrine-Disrupting Compounds of the Past and Present
Source:
Endocrine Disruptors, Brain, and Behavior
Author(s):

Heather B. Patisaul

Scott M. Belcher

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199935734.003.0003

This chapter focuses on four of the best known and most well characterized EDCs: the polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), diethylstilbestrol (DES), and bisphenol A (BPA) as prototypical EDCs. For each compound, historical information regarding use, sources of contamination, descriptions of toxic effects, nature of endocrine disruptive mechanisms, and detailed summaries of critical research findings are highlighted. Each of these chemicals are seminal illustrative examples of EDCs that came to be recognized, defined, and considered seriously by the general public and the regulatory community. Continuing work with these well-studied chemicals continues to reveal new mechanisms of EDC action and identifying new potential health outcomes and effects, and have become important “positive control chemicals” for toxicity and chemical testing strategies and identification of emerging EDCs.

Keywords:   bisphenol, DDT, DES, diethylstilbestrol, endocrine disruption, exposure, mechanism, PCB, toxicity

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