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Endocrine Disruptors, Brain, and Behavior$
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Heather B. Patisaul and Scott M. Belcher

Print publication date: 2017

Print ISBN-13: 9780199935734

Published to Oxford Scholarship Online: May 2017

DOI: 10.1093/acprof:oso/9780199935734.001.0001

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Receptor and Enzyme Mechanisms as Targets for Endocrine Disruptors

Receptor and Enzyme Mechanisms as Targets for Endocrine Disruptors

(p.107) Chapter 5 Receptor and Enzyme Mechanisms as Targets for Endocrine Disruptors
Endocrine Disruptors, Brain, and Behavior

Heather B. Patisaul

Scott M. Belcher

Oxford University Press

In this chapter, the current understanding of the mechanisms of endocrine disruption on the brain and nervous system are presented. Because the overwhelming majority of mechanistic studies on EDCs have focused on the actions mediated by nuclear hormone receptors, this mechanisms is described in detail. The chapter also discusses the classic transcriptional mechanisms of steroid action and the impact of EDCs on rapid signaling (non-genomic) mechanisms. It presents an overview of the enzymes and pathways involved in the biosynthesis of steroid hormones, which are critical to proper functioning of the HPA and HPG axis, and the neuroactive steroids synthesized and active in the mammalian brain. The potential for EDCs to alter metabolic enzymes, with a focus on possible targets in the metabolic blood-brain barrier, is presented as a potential, though largely unexplored, mode of EDC action in the brain.

Keywords:   blood-brain barrier, endocrine disruption, brain, enzyme, hormone, biosynthesis

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