Jump to ContentJump to Main Navigation
Endocrine Disruptors, Brain, and Behavior$
Users without a subscription are not able to see the full content.

Heather B. Patisaul and Scott M. Belcher

Print publication date: 2017

Print ISBN-13: 9780199935734

Published to Oxford Scholarship Online: May 2017

DOI: 10.1093/acprof:oso/9780199935734.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use.date: 28 June 2022

Receptor and Enzyme Mechanisms as Targets for Endocrine Disruptors

Receptor and Enzyme Mechanisms as Targets for Endocrine Disruptors

Chapter:
(p.107) Chapter 5 Receptor and Enzyme Mechanisms as Targets for Endocrine Disruptors
Source:
Endocrine Disruptors, Brain, and Behavior
Author(s):

Heather B. Patisaul

Scott M. Belcher

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199935734.003.0005

In this chapter, the current understanding of the mechanisms of endocrine disruption on the brain and nervous system are presented. Because the overwhelming majority of mechanistic studies on EDCs have focused on the actions mediated by nuclear hormone receptors, this mechanisms is described in detail. The chapter also discusses the classic transcriptional mechanisms of steroid action and the impact of EDCs on rapid signaling (non-genomic) mechanisms. It presents an overview of the enzymes and pathways involved in the biosynthesis of steroid hormones, which are critical to proper functioning of the HPA and HPG axis, and the neuroactive steroids synthesized and active in the mammalian brain. The potential for EDCs to alter metabolic enzymes, with a focus on possible targets in the metabolic blood-brain barrier, is presented as a potential, though largely unexplored, mode of EDC action in the brain.

Keywords:   blood-brain barrier, endocrine disruption, brain, enzyme, hormone, biosynthesis

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .