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Endocrine Disruptors, Brain, and Behavior$
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Heather B. Patisaul and Scott M. Belcher

Print publication date: 2017

Print ISBN-13: 9780199935734

Published to Oxford Scholarship Online: May 2017

DOI: 10.1093/acprof:oso/9780199935734.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use.date: 27 May 2022

The Path Forward

The Path Forward

(p.227) Chapter 8 The Path Forward
Endocrine Disruptors, Brain, and Behavior

Heather B. Patisaul

Scott M. Belcher

Oxford University Press

This chapter focuses on the contemporary approaches of research being used to understand the actions of EDCs and emerging high-throughput screening approaches to examine new and existing chemicals for endocrine-disrupting activities. Concepts arising from the 2007 NRC report “Toxicity Testing in the 21st Century: A Vision and a Strategy” are delineated and the ongoing development of predictive computational toxicology approaches are addressed. The screening strategies being developed under the Tox21 and Toxicity Forecaster (ToxCast) programs are described, with a review of advantages, challenges, and progress to date. There is a brief overview of the EPA’s Interactive Chemical Safety for Sustainability (iCSS) Dashboard as a portal for accessing the ToxCast data through ToxCastDB, and the EPA’s Aggregated Computational Toxicology data warehouse (ACToR), which contains all publicly available EPA chemical toxicity data. Additional challenges related to the inability of current screening approaches to address complex physiology involved in neuroendocrine disruption are addressed.

Keywords:   EPA, toxicity, neuroendocrine disruption, screening, Tox21, ToxCast

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