Jump to ContentJump to Main Navigation
Immune Responses in the Nervous System$
Users without a subscription are not able to see the full content.

Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 04 December 2020

The blood–brain barrier and perivascular cells

The blood–brain barrier and perivascular cells

(p.1) Chapter 1 The blood–brain barrier and perivascular cells
Immune Responses in the Nervous System

Barbro B. Johansson

Oxford University Press

This chapter discusses the blood-brain (BBB) barrier and perivascular cells. The BBB is a dynamic and complex interface between blood and brain enabling an optimal internal environment for neurons and glial cells. It is uncertain if cytokines enter the brain from the blood. Whatever the signaling mechanisms, it is clear that peripheral cytokines can influence the brain and that cytokines can be released by microglia and other cells, including brain endothelial cells, thereby enhancing passage of leukocytes and macrophages into the brain. The role of neutrophils and macrophages in the pathomechanism of the BBB alteration, edema formation, and cell damage in meningitis, trauma, and vascular lesions needs further evaluation.

Keywords:   neurons, glial cells, cytokines, leukocytes, macrophages, neutrophils

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .