Jump to ContentJump to Main Navigation
Immune Responses in the Nervous System$
Users without a subscription are not able to see the full content.

Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 27 November 2020

The role of glial cells in immune responses in the brain

The role of glial cells in immune responses in the brain

(p.61) Chapter 3 The role of glial cells in immune responses in the brain
Immune Responses in the Nervous System

Jochen Gehrmann

Richard B. Banati

Oxford University Press

Immune reactions in the brain are largely controlled by the interaction between extrinsic immuneffector cells such as T and B cells, and resident glial cell populations. T and B lymphocytes recruited from peripheral immune organs constitute the main extrinsic effector cells, while microglia and astrocytes become rapidly activated as part of an intrinsic immune defence of the brain against such an immune injury. Pathophysiologically important, myelinforming oligodendrocytes are particularly vulnerable during central nervous system (CNS) immune injury. In demyelinating diseases, like multiple sclerosis, injury to oligodendrocytes as well as to components of the CNS myelin sheath plays an important role. This chapter focuses on the involvement of these different cell types during autoimmune injury, with a particular emphasis on intercellular communication between activated glial cells and lymphocytes via cytokines and other mediators.

Keywords:   immune reactions, autoimmune injury, intercellular communication, glial cells, lymphocytes, cytokines, central nervous system

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .