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Immune Responses in the Nervous System$
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Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

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Neurotrophins: aspects of their in vivo action and physiology

Neurotrophins: aspects of their in vivo action and physiology

(p.101) Chapter 5 Neurotrophins: aspects of their in vivo action and physiology
Immune Responses in the Nervous System

Michael Meyer

Oxford University Press

This chapter discusses selected aspects of the biology of neurotrophins in the context of three major questions. First, what methods are available today to study the physiology of neurotrophins and how do they compare with methods used previously? Second, what do we learn from discrepancies between the in vitro and in vivo actions of neurotrophins? Third, what is the lesson from discrepancies between the effects of neurotrophins observed in pathophysiological situations as compared with physiological contexts? Null mutations of genes encoding neurotrophins (with the exception of NT-4 and p75) and their receptors in mice severely compromise postnatal development, demonstrating that lack of these pathways cannot be fully compensated for. These results demonstrate that, although neurotrophin signalling is essential for the existence of this species, redundant safety mechanisms have not been introduced during evolution.

Keywords:   neurotrophins, physiology, postnatal development, neurotrophin signalling

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