Jump to ContentJump to Main Navigation
Immune Responses in the Nervous System$
Users without a subscription are not able to see the full content.

Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 28 November 2020

Central nervous system immune reactions in Alzheimer's disease

Central nervous system immune reactions in Alzheimer's disease

(p.143) Chapter 7 Central nervous system immune reactions in Alzheimer's disease
Immune Responses in the Nervous System

Patrick L. McGeer

Edith G. McGeer

Oxford University Press

Alzheimer's disease (AD) is a relentlessly progressive dementing disorder with an incidence that increases very sharply with age. Of the many potential bases for neurodegeneration in AD, immune-directed attack is one of the most easily conceived because such processes are inherently destructive. Typically, this destruction is beneficial to the host, as in the warding off of extrinsic pathogens. Sometimes it is not, as in autoimmune diseases. This chapter describes evidence that there is a prominent immune response in AD. Particular attention is given to the autodestructive forces that are inherent to such a response, and the potential harm they can cause. The possibility of ameliorating such damage through the use of anti-inflammatory drugs is discussed.

Keywords:   dementia, immune response, autodestruction, neurodegeneration

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .