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Codon EvolutionMechanisms and Models$
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Gina M. Cannarozzi and Adrian Schneider

Print publication date: 2012

Print ISBN-13: 9780199601165

Published to Oxford Scholarship Online: May 2015

DOI: 10.1093/acprof:osobl/9780199601165.001.0001

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Use of codon models in molecular dating and functional analysis

Use of codon models in molecular dating and functional analysis

(p.133) Chapter 10 Use of codon models in molecular dating and functional analysis
Codon Evolution

Steven A. Benner

Oxford University Press

This chapter focuses on the use of codon models for molecular dating and functional analysis, with a critical view on the actual usefulness of models on practical problems. According to Darwinian theory, a statement about function explains how a gene and its encoded protein confer fitness upon a host organism. This chapter addresses how detailed analysis of gene sequences within the context of the genetic code can help make these statements. It begins by describing the level of analysis most useful for functional biology. It then discusses approaches to improve codon analysis and presents studies of molecular clocks.

Keywords:   codon models, molecular dating, functional analysis, functional biology, molecular clock

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