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Codon EvolutionMechanisms and Models$
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Gina M. Cannarozzi and Adrian Schneider

Print publication date: 2012

Print ISBN-13: 9780199601165

Published to Oxford Scholarship Online: May 2015

DOI: 10.1093/acprof:osobl/9780199601165.001.0001

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Detecting and understanding natural selection

Detecting and understanding natural selection

(p.73) Chapter 6 Detecting and understanding natural selection
Codon Evolution

Maria Anisimova

David A. Liberles

Oxford University Press

Natural selection plays an important role in the phenotypic variation. In recent years, codon models have found widespread use in the detection of selection. This chapter focuses on the phenomenon of selection and reviews current models employed to detect selection. It discusses a range of statistical methods used to study selection in molecular sequences based on inter-specific comparisons or within a population. It outlines several methodological challenges, and addresses common misconceptions of the statistical modelling in the context of detecting selection. Finally, it briefly reviews recent conclusions from large-scale genomic studies and their applications in the emerging field of the evolutionary medicine.

Keywords:   natural selection, phenotypic variation, codon models, statistical methods, evolutionary medicine, genome

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