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Cancer Epidemiology and Prevention$
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Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

Print publication date: 2017

Print ISBN-13: 9780190238667

Published to Oxford Scholarship Online: December 2017

DOI: 10.1093/oso/9780190238667.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 19 October 2021

Hormones and Cancer

Hormones and Cancer

(p.395) 22 Hormones and Cancer
Cancer Epidemiology and Prevention

Robert N. Hoover

Amanda Black

Rebecca Troisi

Oxford University Press

Hormones are highly biologically active endogenous compounds that control the growth, development, physiology, and homeostasis of numerous organ systems. Because of this, they have long been thought likely to play key roles in both normal and abnormal (malignant) growth. They are also noteworthy for being produced away from the tissues that they control, and are thus secreted into circulating blood to reach their target organs. This combination of potent, targeted agents of growth and development that can be measured in available biologic fluids has made steroidal and peptide hormonesparticularly susceptible and relevant to epidemiologic investigation. In addition, medications containing hormones and hormone antagonists have come into widespread use, providing further opportunities for epidemiologic insights into hormonal carcinogenesis. The development of increasingly more accurate assays to measure sex hormones and their metabolites has resulted in major advances in understanding the hormonal etiology of breast and gynecologic malignancies.

Keywords:   hormones, cancer, hormonal carcinogenesis, breast cancer, epidemiology

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