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Cancer Epidemiology and Prevention$
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Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

Print publication date: 2017

Print ISBN-13: 9780190238667

Published to Oxford Scholarship Online: December 2017

DOI: 10.1093/oso/9780190238667.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 19 October 2021

Cancer of the Pancreas

Cancer of the Pancreas

(p.611) 32 Cancer of the Pancreas
Cancer Epidemiology and Prevention

Samuel O. Antwi

Rick J. Jansen

Gloria M. Petersen

Oxford University Press

Pancreatic cancer (PC) is an uncommon but often rapidly lethal malignancy. Worldwide, PC is the twelfth most commonly diagnosed cancer and the seventh most common for cancer deaths. Globally, the estimated number of incident cases (338,000) and deaths from PC (330,400) were almost identical in 2012 Etiologic research on PC is complicated by the relatively inaccessible location of the pancreas, obstacles to early diagnosis, aggressiveness and resistance to therapy of these malignancies, and the tendency of PC to progress rapidly. Until recently, the only etiologic factors considered to be definite causes of PC were tobacco use, chronic pancreatitis, and several rare high-penetrance genetic disorders. In the past decade, the evidence for other causal relationships has strengthened, especially for metabolic risk factors (obesity, type II diabetes mellitus, insulin and insulin-like growth factor), chronic local inflammation, heavy alcohol consumption, dietary consumption of grilled meat, and non-O ABO blood type.

Keywords:   pancreatic cancer, etiology, risk factors, smoking, obesity, pancreatitis

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